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Reduced Scanning-Time with a Dual-Injection Protocol for Dynamic Whole-Body PET

Erlandsson, K; Kotasidis, F; Jansen, F; Hutton, BF; Thielemans, K; (2024) Reduced Scanning-Time with a Dual-Injection Protocol for Dynamic Whole-Body PET. In: 2022 IEEE NSS/MIC RTSD - IEEE Nuclear Science Symposium, Medical Imaging Conference and Room Temperature Semiconductor Detector Conference. IEEE: Italy. Green open access

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Abstract

Dynamic whole-body (DWB) PET data for irreversible tracers, such as [18F]-FDG, can be obtained with conventional PET scanners using multi-bed multi-pass data acquisition protocols, providing parametric images, which are more informative than standard SUV images. The drawback is a relatively long scanning time. Recently, a dual injection protocol with a reduced scanning time was proposed for a total-body PET scanner (Wu et al., JNM 2022). We developed a dual-injection protocol for a conventional PET scanner with multi-bed multi-pass acquisition. The input function is derived from the heart or aorta, and fitted with an analytical function, with the 1st part being obtained after the 2nd injection. Two different models were used for fitting the time-activity curves: standard compartmental modelling (CM) and a combination of CM and Patlak analysis. We have evaluated the protocol using computer simulations, and investigated the effect of different injection fractions, injection time-points, scan start-times as well as different values of blood volume (Vb) and tracer non-irreversibility (k4). Our results showed that the injection fraction and time point for the 2nd injection had minor impact on the estimated parameters. While a late scan start time as well as non-zero Vb or k4 values could result in bias. Both bias and variance were lower with the combined model as compared to the standard model. Also, the parameter estimation was not very sensitive to errors in injection fraction with the combined model. In conclusion, we found that the proposed protocol is feasible for obtaining dynamic whole-body PET data with irreversible tracers, using the multi-bed multi-pass acquisition protocol, while still measuring individual AIFs.

Type: Proceedings paper
Title: Reduced Scanning-Time with a Dual-Injection Protocol for Dynamic Whole-Body PET
Event: 2022 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Dates: 5 Nov 2022 - 12 Nov 2022
ISBN-13: 9781665488723
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/NSS/MIC44845.2022.10399267
Publisher version: http://dx.doi.org/10.1109/nss/mic44845.2022.103992...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Heart, Analytical models, Protocols, Parameter estimation, Computational modeling, Whole-body PET, Standards
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/10189342
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