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[¹⁸F]FDG PET/CT Signal Correlates with Neoangiogenesis Markers in Patients with Fibrotic Interstitial Lung Disease Who Underwent Lung Biopsy: Implication for the Use of PET/CT in Diffuse Lung Diseases

Porter, Joanna C; Ganeshan, Balaji; Win, Thida; Fraioli, Francesco; Khan, Saif; Rodriguez-Justo, Manuel; Endozo, Raymond; ... Groves, Ashley M; + view all (2024) [¹⁸F]FDG PET/CT Signal Correlates with Neoangiogenesis Markers in Patients with Fibrotic Interstitial Lung Disease Who Underwent Lung Biopsy: Implication for the Use of PET/CT in Diffuse Lung Diseases. Journal of Nuclear Medicine , 65 (3) , Article jnumed.123.266445. 10.2967/jnumed.123.266445. Green open access

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Abstract

The use of [¹⁸F]FDG PET/CT as a biomarker in diffuse lung diseases is increasingly recognized. We investigated the correlation between [¹⁸F]FDG uptake with histologic markers on lung biopsy of patients with fibrotic interstitial lung disease (fILD). // Methods: We recruited 18 patients with fILD awaiting lung biopsy for [¹⁸F]FDG PET/CT. We derived a target-to-background ratio (TBR) of maximum pulmonary uptake of [¹⁸F]FDG (SUVₘₐₓ) divided by the lung background (SUVₘᵢₙ). Consecutive paraffin-embedded lung biopsy sections were immunostained for alveolar and interstitial macrophages (CD68), microvessel density (MVD) (CD31 and CD105/endoglin), and glucose transporter 1. MVD was expressed as vessel area percentage per high-power field (Va%/hpf). Differences in imaging and angiogenesis markers between histologic usual interstitial pneumonia (UIP) and non-UIP were assessed using a nonparametric Mann–Whitney test. Correlation of imaging with angiogenesis markers was assessed using the nonparametric Spearman rank correlation. Univariate Kaplan–Meier survival analysis assessed the difference in the survival curves for each of the angiogenesis markers (separated by their respective optimal cutoff) using the log-rank test. Statistical analysis was performed using SPSS. // Results: In total, 18 patients were followed for an average of 41.36 mo (range, 5.69–132.46 mo; median, 30.07 mo). Only CD105 MVD showed a significantly positive correlation with [¹⁸F]FDG TBR (Spearman rank correlation, 0.556; P < 0.05, n = 13). There was no correlation between [¹⁸F]FDG uptake and macrophage expression of glucose transporter 1. CD105 and CD31 were higher for UIP than for non-UIP, with CD105 reaching statistical significance (P = 0.011). In all patients, MVD assessed with either CD105 or CD31 quantification on biopsy predicted overall survival. Patients with CD105 MVD of less than 12 Va%/hpf or CD31 MVD of less than 35 Va%/hpf had a significantly better prognosis (no deaths during follow-up in the case of CD105) than did patients with higher scores of CD105 MVD (median survival, 35 mo; P = 0.041, n = 13) or CD31 MVD (median survival, 28 mo; P = 0.014, n = 13). // Conclusion: Previous work has used [¹⁸F]FDG uptake in PET/CT as a biomarker in fILD. Here, we highlight a correlation between angiogenesis and [¹⁸F]FDG TBR. We show that MVD is higher for UIP than for non-UIP and is associated with mortality in patients with fILD. These data set the scene to investigate the potential role of vasculature and angiogenesis in fibrosis.

Type: Article
Title: [¹⁸F]FDG PET/CT Signal Correlates with Neoangiogenesis Markers in Patients with Fibrotic Interstitial Lung Disease Who Underwent Lung Biopsy: Implication for the Use of PET/CT in Diffuse Lung Diseases
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.2967/jnumed.123.266445
Publisher version: https://doi.org/10.2967/jnumed.123.266445
Language: English
Additional information: © 2024 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/.
Keywords: ILD, [¹⁸F]FDG PET/CT, angiogenesis, fibrosis, microvessel
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10189310
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