Azzarelli, Roberta;
Simons, Benjamin D;
Philpott, Anna;
(2018)
The developmental origin of brain tumours: a cellular and molecular framework.
Development
, 145
(10)
, Article dev162693. 10.1242/dev.162693.
Preview |
Text
Azzarelli Development 2018.pdf - Other Download (611kB) | Preview |
Abstract
The development of the nervous system relies on the coordinated regulation of stem cell self-renewal and differentiation. The discovery that brain tumours contain a subpopulation of cells with stem/ progenitor characteristics that are capable of sustaining tumour growth has emphasized the importance of understanding the cellular dynamics and the molecular pathways regulating neural stem cell behaviour. By focusing on recent work on glioma and medulloblastoma, we review how lineage tracing contributed to dissecting the embryonic origin of brain tumours and how lineagespecific mechanisms that regulate stem cell behaviour in the embryo may be subverted in cancer to achieve uncontrolled proliferation and suppression of differentiation.
Type: | Article |
---|---|
Title: | The developmental origin of brain tumours: a cellular and molecular framework |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1242/dev.162693 |
Publisher version: | https://doi.org/10.1242/dev.162693 |
Language: | English |
Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
URI: | https://discovery.ucl.ac.uk/id/eprint/10189179 |
Archive Staff Only
![]() |
View Item |