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The developmental origin of brain tumours: a cellular and molecular framework

Azzarelli, Roberta; Simons, Benjamin D; Philpott, Anna; (2018) The developmental origin of brain tumours: a cellular and molecular framework. Development , 145 (10) , Article dev162693. 10.1242/dev.162693. Green open access

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Abstract

The development of the nervous system relies on the coordinated regulation of stem cell self-renewal and differentiation. The discovery that brain tumours contain a subpopulation of cells with stem/ progenitor characteristics that are capable of sustaining tumour growth has emphasized the importance of understanding the cellular dynamics and the molecular pathways regulating neural stem cell behaviour. By focusing on recent work on glioma and medulloblastoma, we review how lineage tracing contributed to dissecting the embryonic origin of brain tumours and how lineagespecific mechanisms that regulate stem cell behaviour in the embryo may be subverted in cancer to achieve uncontrolled proliferation and suppression of differentiation.

Type: Article
Title: The developmental origin of brain tumours: a cellular and molecular framework
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.162693
Publisher version: https://doi.org/10.1242/dev.162693
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/10189179
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