Azzarelli, Roberta;
Pacary, Emilie;
Garg, Ritu;
Garcez, Patricia;
van den Berg, Debbie;
Riou, Philippe;
Ridley, Anne J;
... Guillemot, Francois; + view all
(2014)
An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.
Nature Communications
, 5
, Article 3405. 10.1038/ncomms4405.
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Abstract
A transcriptional programme initiated by the proneural factors Neurog2 and Ascl1 controls successive steps of neurogenesis in the embryonic cerebral cortex. Previous work has shown that proneural factors also confer a migratory behaviour to cortical neurons by inducing the expression of the small GTP-binding proteins such as Rnd2 and Rnd3. However, the directionality of radial migration suggests that migrating neurons also respond to extracellular signal-regulated pathways. Here we show that the Plexin B2 receptor interacts physically and functionally with Rnd3 and stimulates RhoA activity in migrating cortical neurons. Plexin B2 competes with p190RhoGAP for binding to Rnd3, thus blocking the Rnd3-mediated inhibition of RhoA and also recruits RhoGEFs to directly stimulate RhoA activity. Thus, an interaction between the cell-extrinsic Plexin signalling pathway and the cell-intrinsic Ascl1-Rnd3 pathway determines the level of RhoA activity appropriate for cortical neuron migration.
Type: | Article |
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Title: | An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1038/ncomms4405 |
Publisher version: | https://doi.org/10.1038/ncomms4405 |
Language: | English |
Additional information: | This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/3.0/ |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
URI: | https://discovery.ucl.ac.uk/id/eprint/10189172 |
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