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BCL6 deletion in CD4 T cells does not affect Th2 effector mediated immunity in the skin

Chandler, Jodie; Prout, Melanie; Old, Sam; Morgan, Cynthia; Ronchese, Franca; Benoist, Christophe; Le Gros, Graham; (2022) BCL6 deletion in CD4 T cells does not affect Th2 effector mediated immunity in the skin. Immunology & Cell Biology , 100 (10) pp. 791-804. 10.1111/imcb.12589. Green open access

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Abstract

Recent studies propose that T follicular helper (Tfh) cells possess a high degree of functional plasticity in addition to their well‐defined roles in mediating interleukin‐4‐dependent switching of germinal center B cells to the production of immunoglobulin (Ig)G1 and IgE antibodies. In particular Tfh cells have been proposed to be an essential stage in Th2 effector cell development that are able to contribute to innate type 2 responses. We used CD4‐cre targeted deletion of BCL6 to identify the contribution Tfh cells make to tissue Th2 effector responses in models of atopic skin disease and lung immunity to parasites. Ablation of Tfh cells did not impair the development or recruitment of Th2 effector subsets to the skin and did not alter the transcriptional expression profile or functional activities of the resulting tissue resident Th2 effector cells. However, the accumulation of Th2 effector cells in lung Th2 responses was partially affected by BCL6 deficiency. These data indicate that the development of Th2 effector cells does not require a BCL6 dependent step, implying Tfh and Th2 effector populations follow separate developmental trajectories and Tfh cells do not contribute to type 2 responses in the skin.

Type: Article
Title: BCL6 deletion in CD4 T cells does not affect Th2 effector mediated immunity in the skin
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/imcb.12589
Publisher version: http://dx.doi.org/10.1111/imcb.12589
Language: English
Additional information: © 2022 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10189149
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