Lopez Maury, Luis;
Ren, Liping;
Hassan, Shaimaa;
Bähler, Jürg;
Gould, Kathleen L;
(2024)
The Cdc14 phosphatase, Clp1, does not affect genome expression.
microPublication Biology
, 2024
10.17912/micropub.biology.001089.
(In press).
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Abstract
Schizosaccharomyces pombe Clp1 is a Cdc14-family phosphatase that reverses mitotic Cdk1 phosphorylation. Despite evolutionary conservation, Clp1 's mammalian orthologs do not share this function. Rather, higher eukaryotic Cdc14 enzymes act in DNA repair, ciliogenesis, and gene regulation. To examine if Clp1 regulates gene expression, we compared the transcriptional profiles of cells lacking Clp1 function to that of wildtype. Because clp1∆ cells are sensitive to the actin depolymerizing drug, LatrunculinA, we also investigated whether a transcriptional response was involved. Our results indicate that Clp1 does not detectably affect gene expression and highlight the organism-specific functions of this conserved phosphatase family.
| Type: | Article |
|---|---|
| Title: | The Cdc14 phosphatase, Clp1, does not affect genome expression |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.17912/micropub.biology.001089 |
| Publisher version: | http://doi.org/10.17912/micropub.biology.001089 |
| Language: | English |
| Additional information: | © 2024 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10188661 |
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