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Medical, surgical, and physical treatments for Parkinson's disease

Foltynie, Tom; Bruno, Veronica; Fox, Susan; Kühn, Andrea A; Lindop, Fiona; Lees, Andrew J; (2024) Medical, surgical, and physical treatments for Parkinson's disease. The Lancet , 403 (10423) pp. 305-324. 10.1016/S0140-6736(23)01429-0.

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Abstract

Although dopamine replacement therapy remains a core component of Parkinson's disease treatment, the onset of motor fluctuations and dyskinetic movements might require a range of medical and surgical approaches from a multidisciplinary team, and important new approaches in the delivery of dopamine replacement are becoming available. The more challenging, wide range of non-motor symptoms can also have a major impact on the quality of life of a patient with Parkinson's disease, and requires careful multidisciplinary management using evidence-based knowledge, as well as appropriately tailored strategies according to the individual patient's needs. Disease-modifying therapies are urgently needed to prevent the development of the most disabling refractory symptoms, including gait and balance difficulties, cognitive impairment and dementia, and speech and swallowing impairments. In the third paper in this Series, we present the latest evidence supporting the optimal treatment of Parkinson's disease, and describe an expert approach to many aspects of treatment choice where an evidence base is insufficient.

Type: Article
Title: Medical, surgical, and physical treatments for Parkinson's disease
Location: England
DOI: 10.1016/S0140-6736(23)01429-0
Publisher version: http://dx.doi.org/10.1016/s0140-6736(23)01429-0
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Humans, Parkinson Disease, Dopamine, Quality of Life, Cognitive Dysfunction, Patient Selection
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10187284
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