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Precision Targeting of Mutant PI3Kα

Gong, Grace Q; Vanhaesebroeck, Bart; (2024) Precision Targeting of Mutant PI3Kα. Cancer Discovery , 14 (2) pp. 204-207. 10.1158/2159-8290.cd-23-1392.

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Abstract

PIK3CA, which encodes the p110α catalytic subunit of PI 3-kinase alpha (PI3Kα), is one of the most frequently genetically activated kinases in solid tumors. In two back-to-back papers, Varkaris and colleagues report on the development of a novel allosteric PI3Kα-mutant–selective inhibitor and early clinical experience with this compound. See related article by Varkaris et al., p. 227 (6) . See related article by Varkaris et al., p. 240 (5) .

Type: Article
Title: Precision Targeting of Mutant PI3Kα
DOI: 10.1158/2159-8290.cd-23-1392
Publisher version: http://dx.doi.org/10.1158/2159-8290.cd-23-1392
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10187005
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