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Cataract Surgery Outcomes in Retinitis Pigmentosa A Comparative Clinical Database Study

Georgiou, Michalis; Shakarchi, Ahmed F; Elhusseiny, Abdelrahman M; Michaelides, Michel; Sallam, Ahmed B; (2024) Cataract Surgery Outcomes in Retinitis Pigmentosa A Comparative Clinical Database Study. American Journal of Ophthalmology , 262 pp. 34-39. 10.1016/j.ajo.2024.01.037. Green open access

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Abstract

PURPOSE: To report visual acuity (VA) outcomes, intraoperative and postoperative complications of isolated cataract surgery in eyes with retinitis pigmentosa (RP), compared with non-RP-affected eyes. DESIGN: Retrospective clinical cohort study. METHODS: A total of 113,389 eyes underwent cataract surgery between December 2010 and December 2014 at 8 clinical sites in the United Kingdom. Eyes with RP as the only comorbid pathology and eyes without any ocular comorbidities (controls) undergoing cataract surgery were compared. VA at 4-12 weeks postoperatively and rates of intraoperative and postoperative complications are reported. RESULTS: Seventy-two eyes had RP. The mean age in the RP group was 57±15 compared to 75±10 in controls (p<0.001). Females represented 46% of RP cases and 60% of controls (p=0.06). Preoperative VA (mean LogMAR = 1.03 vs 0.59, p<0.001) and postoperative VA (0.71 vs 0.14, p<0.001) were worse in RP. The mean VA gain was 0.25±0.60 LogMAR in RP vs 0.43±0.48 LogMAR in controls (p<0.001). There were no significant differences in the rate of intraoperative pupil expansion use, posterior capsular tears, or zonular dialysis. Postoperative cystoid macular edema developed in 6.9% of RP eyes and 1% of controls (p<0.001). The need for IOL repositioning or exchange was not statistically different between the two groups. CONCLUSION: Cataract surgery can improve vision in eyes with RP and cataract. Intraoperative complications were similar to control eyes; however, RP eyes experienced more frequent postoperative cystoid macular edema.

Type: Article
Title: Cataract Surgery Outcomes in Retinitis Pigmentosa A Comparative Clinical Database Study
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ajo.2024.01.037
Publisher version: http://dx.doi.org/10.1016/j.ajo.2024.01.037
Language: English
Additional information: Copyright © 2024 The Authors. This is an open access article under the CC BY licence (https://creativecommons.org/licenses/by/4.0/).
Keywords: RP, cataract, complications zonular dialysis, cystoid macular edema, retinal dystrophy, retinitis pigmentosa
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10186833
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