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Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration

Hunter, AML; Anderson, RS; Redmond, T; Garway-Heath, DF; Mulholland, PJ; (2023) Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration. Translational Vision Science and Technology , 12 (11) , Article 37. 10.1167/tvst.12.11.37. Green open access

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Abstract

Purpose: To measure achromatic spatial, temporal, and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls under conditions of photopic gaze-contingent perimetry. Methods: Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco’s area (RA) at 2.5° and 5° eccentricities along the 0°, 90°, 180°, and 270° meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7–190.4 ms) with a Goldmann III stimulus (GIII, 0.43°) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal summation (using the GIII stimulus) and spatiotempo-ral summation (using the RA stimuli) was estimated using iterative two-phase regression analysis. Results: Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09–0.41] deg2; 5°: 0.32 [0.15–0.65 deg2 ]) compared to healthy controls (2.5°: 0.08 [0.05–0.13] deg2; 5°: 0.15 [0.08–0.22] deg2 ) at all test locations (all P < 0.05). No significant difference in median critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9–30.4] ms) and RA-scaled stimuli (22.9 [13.9–40.3] ms) compared to healthy controls (GIII: 17.0 [11.3–24.0] ms; RA-scaled: 22.4 [14.3–33.1] ms) at all test locations (all P > 0.05). Conclusions: Spatial summation is altered in dry AMD, without commensurate changes in temporal summation. Translational Relevance: The sensitivity of perimetry to AMD may be improved by utilizing stimuli that probe alterations in spatial summation in the disease.

Type: Article
Title: Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/tvst.12.11.37
Publisher version: http://dx.doi.org/10.1167/tvst.12.11.37
Language: English
Additional information: Copyright © 2023 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Keywords: Humans, Aged, Visual Field Tests, Geographic Atrophy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10186746
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