Doyle, Katie;
Magbagbeola, Morenike;
Rai, Zainab L;
Waterhouse, Dale;
Lindenroth, Lukas;
Dwyer, George;
Gander, Amir;
... Stoyanov, Danail; + view all
(2023)
The Application of Machine Perfusion as an Enhanced ex vivo Model for Optical Imaging.
In:
Proceedings of the 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) 2023.
(pp. pp. 1-7).
Institute of Electrical and Electronics Engineers (IEEE)
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Abstract
Optical imaging techniques such as spectral imaging show promise for the assessment of tissue health during surgery; however, the validation and translation of such techniques into clinical practise is limited by the lack of representative tissue models. In this paper, we demonstrate the application of an organ perfusion machine as an ex vivo tissue model for optical imaging. Three porcine livers are perfused at stepped blood oxygen saturations. Over the duration of each perfusion, spectral data of the tissue are captured via diffuse optical spectroscopy and multispectral imaging. These data are synchronised with blood oxygen saturation measurements recorded by the perfusion machine. Shifts in the optical properties of the tissue are demonstrated over the duration of the each perfusion, as the tissue becomes reperfused and as the oxygen saturation is varied.
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