Sinclair, H;
Ranji, T;
Gilbert, DC;
(2024)
Will Immune Checkpoint Inhibitors Allow the Non-operative Management of Mismatch Repair-deficient Colorectal Cancer to Become a Standard of Care?
Clinical Oncology
10.1016/j.clon.2024.01.006.
(In press).
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Abstract
DNA mismatch repair (MMR) is essential for the detection and replacement of single-nucleotide mismatches that occur during cell replication. Loss of function of MMR proteins (germ line) is the underlying cause of Lynch syndrome and is seen in a proportion of sporadic colorectal cancers (CRC), either through somatic mutation or methylation. Deficiency of MMR activity (dMMR) results in accumulation of single-nucleotide variants and frameshifts, high rates of mutation and variation in the repetitive microsatellite regions found within the genome – known as high microsatellite instability [1].
| Type: | Article |
|---|---|
| Title: | Will Immune Checkpoint Inhibitors Allow the Non-operative Management of Mismatch Repair-deficient Colorectal Cancer to Become a Standard of Care? |
| Location: | England |
| DOI: | 10.1016/j.clon.2024.01.006 |
| Publisher version: | http://dx.doi.org/10.1016/j.clon.2024.01.006 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10186567 |
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