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Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy

Alexiadou, Kleopatra; Ansari, Saleem; Jones, Bryony; Yu, Christina; Dornhorst, Anne; Oliver, Nick; Tsironis, Christos; ... Tan, Tricia M-M; + view all (2024) Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy. BMJ Open Diabetes Research & Care , 12 (1) , Article e003642. 10.1136/bmjdrc-2023-003642. Green open access

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Abstract

Introduction: Bariatric surgery is associated with adverse pregnancy outcomes such as reduced birth weight and premature birth. One possible mechanism for this is increased glycemic variability (GV) which occurs after bariatric surgery. The objective of this study was to compare the effect of Roux-en-Y gastric bypass (RYGB) versus vertical sleeve gastrectomy (SG) on GV during pregnancy and to investigate the relationships of GV, type of bariatric surgery and maternal and neonatal outcomes. // Research design and methods: Fourteen pregnant women after RYGB and 14 after SG were investigated with continuous glucose monitoring in their second or third trimester in this observational study carried out as part of routine clinical care. // Results: Pregnant women with RYGB had similar mean interstitial glucose values but significantly increased indices of GV and a lower %time in range 3.9–7.8 mmol/L (70–140 mg/dL), compared with SG. // Conclusions: Pregnant women who have undergone RYGB have greater GV during pregnancy compared with those who have undergone SG. Further research is needed to establish the relationship between GV and pregnancy outcomes to determine the preferred bariatric operation in women of reproductive age, and whether interventions to reduce GV might improve outcomes.

Type: Article
Title: Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bmjdrc-2023-003642
Publisher version: https://doi.org/10.1136/bmjdrc-2023-003642
Language: English
Additional information: Copyright © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10186105
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