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Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors

Reading, James L; Caswell, Deborah R; Swanton, Charles; (2023) Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors. Nature Genetics , 55 (10) pp. 1610-1612. 10.1038/s41588-023-01492-x. Green open access

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Abstract

DNA mismatch repair deficiency (MMRd) is associated with elevated tumor mutational burden (TMB) and exceptional immunotherapy responses, yet some patients experience no clinical benefit. Recent work proposes that high intra-tumoral heterogeneity can offset immunogenicity in sporadic MMRd, suggesting a potential mechanism of immunotherapy failure.

Type: Article
Title: Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41588-023-01492-x
Publisher version: http://dx.doi.org/10.1038/s41588-023-01492-x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10185820
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