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Kidney biopsies among persons living in hotspots of CKDu: a position statement from the International Society of Nephrology’s Consortium of Collaborators on CKDu

Wijewickrama, Eranga; Behera, Suman; Garcia, Pablo; Avila-Casado, Carmen; Caplin, Ben; Paolo, Vicente Sanchez; Courville, Karen; ... ISN i3C Working Group; + view all (2024) Kidney biopsies among persons living in hotspots of CKDu: a position statement from the International Society of Nephrology’s Consortium of Collaborators on CKDu. Kidney International , 105 (3) pp. 464-469. 10.1016/j.kint.2023.12.012. Green open access

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Abstract

Chronic kidney disease of unknown etiology (CKDu) is a progressive primary tubulointerstitial kidney disease affecting persons in rural, agricultural communities worldwide. Some of the other terms used to identify this disease include Mesoamerican nephropathy (MeN) in Central America, Uddanam nephropathy in India, and chronic interstitial nephritis in agricultural communities (CINAC). Well-described hotspots exist in Central America, Sri Lanka, and India, with investigations to assess epidemiology and cause(s) ongoing in many regions of the world.1,2 Although the disease is suggested in a person living in a CKDu endemic area and presenting with declining kidney function without alternative explanations (e.g., diabetes, heavy proteinuria or hematuria indicative of glomerulonephritis, or structural kidney disease), definitive diagnosis requires findings of chronic tubulointerstitial disease on kidney biopsy.

Type: Article
Title: Kidney biopsies among persons living in hotspots of CKDu: a position statement from the International Society of Nephrology’s Consortium of Collaborators on CKDu
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.kint.2023.12.012
Publisher version: http://dx.doi.org/10.1016/j.kint.2023.12.012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10185620
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