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Presynaptic Protein Synthesis in Brain Function and Disease

Castillo, Pablo E; Jung, Hosung; Klann, Eric; Riccio, Antonella; (2023) Presynaptic Protein Synthesis in Brain Function and Disease. The Journal of Neuroscience , 43 (45) pp. 7483-7488. 10.1523/jneurosci.1454-23.2023. Green open access

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Abstract

Local protein synthesis in mature brain axons regulates the structure and function of presynaptic boutons by adjusting the presynaptic proteome to local demands. This crucial mechanism underlies experience-dependent modifications of brain circuits, and its dysregulation may contribute to brain disorders, such as autism and intellectual disability. Here, we discuss recent advancements in the axonal transcriptome, axonal RNA localization and translation, and the role of presynaptic local translation in synaptic plasticity and memory.

Type: Article
Title: Presynaptic Protein Synthesis in Brain Function and Disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/jneurosci.1454-23.2023
Publisher version: http://dx.doi.org/10.1523/jneurosci.1454-23.2023
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Axons, Presynaptic Terminals, Neuronal Plasticity, Brain
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10185534
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