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Framework to optimize fixed-length micro-CT systems for propagation-based phase-contrast imaging

Lioliou, G; BUCHANAN, I; Astolfo, A; Endrizzi, M; Bate, D; Hagen, CK; Olivo, A; (2024) Framework to optimize fixed-length micro-CT systems for propagation-based phase-contrast imaging. Optics Express , 32 (4) pp. 4839-4856. 10.1364/OE.510317. Green open access

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Abstract

A laboratory X-ray imaging system with a setup that closely resembles commercial micro-CT systems with a fixed source-to-detector distance of ∼90 cm is investigated for single distance propagation-based phase-contrast imaging and computed tomography (CT). The system had a constant source-to-detector distance, and the sample positions were optimized. Initially, a PTFE wire was imaged, both in 2D and 3D, to characterize fringe contrast and spatial resolution for different X-ray source settings and source-to-sample distances. The results were compared to calculated values based on theoretical models and to simulated (wave-optics based) results, with good agreement being found. The optimization of the imaging system is discussed. CT scans of two biological samples, a tissue-engineered esophageal scaffold and a rat heart, were then acquired at the optimum parameters, demonstrating that significant image quality improvements can be obtained with widely available components placed inside fixed-length cabinets through proper optimization of propagation-based phase-contrast.

Type: Article
Title: Framework to optimize fixed-length micro-CT systems for propagation-based phase-contrast imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/OE.510317
Publisher version: https://doi.org/10.1364/OE.510317
Language: English
Additional information: Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10185409
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