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Large-scale clustering of AlphaFold2 3D models shines light on the structure and function of proteins

Bordin, Nicola; Lau, Andy M; Orengo, Christine; (2023) Large-scale clustering of AlphaFold2 3D models shines light on the structure and function of proteins. Molecular Cell , 83 (22) pp. 3950-3952. 10.1016/j.molcel.2023.10.039.

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Abstract

Two recent studies exploited ultra-fast structural aligners and deep-learning approaches to cluster the protein structure space in the AlphaFold Database. Barrio-Hernandez et al.1 and Durairaj et al.2 uncovered fascinating new protein functions and structural features previously unknown.

Type: Article
Title: Large-scale clustering of AlphaFold2 3D models shines light on the structure and function of proteins
Location: United States
DOI: 10.1016/j.molcel.2023.10.039
Publisher version: http://dx.doi.org/10.1016/j.molcel.2023.10.039
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cluster Analysis, Databases, Factual
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10185181
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