UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Smoking, Corneal Biomechanics, and Glaucoma: Results From Two Large Population-Based Cohorts

Stuart, Kelsey V; Madjedi, Kian M; Luben, Robert N; Biradar, Mahantesh I; Wagner, Siegfried K; Warwick, Alasdair N; Sun, Zihan; ... Modifiable Risk Factors for Glaucoma Collaboration and the UK Bi; + view all (2024) Smoking, Corneal Biomechanics, and Glaucoma: Results From Two Large Population-Based Cohorts. Investigative Ophthalmology and Visual Science (IOVS) , 65 (1) , Article 11. 10.1167/iovs.65.1.11. Green open access

[thumbnail of i1552-5783-65-1-11_1704197793.72178.pdf]
Preview
PDF
i1552-5783-65-1-11_1704197793.72178.pdf - Published Version

Download (710kB) | Preview

Abstract

PURPOSE: Smoking may influence measured IOP through an effect on corneal biomechanics, but it is unclear whether this factor translates into an increased risk for glaucoma. This study aimed to examine the association of cigarette smoking with corneal biomechanical properties and glaucoma-related traits, and to probe potential causal effects using Mendelian randomization (MR). METHODS: Cross-sectional analyses within the UK Biobank (UKB) and Canadian Longitudinal Study on Aging (CLSA) cohorts. Multivariable linear and logistic regression models were used to assess associations of smoking (status, intensity, and duration) with corneal hysteresis (CH), corneal resistance factor, IOP, inner retinal thicknesses, and glaucoma. Two-sample MR analyses were performed. RESULTS: Overall, 68,738 UKB (mean age, 56.7 years; 54.7% women) and 22 845 CLSA (mean age, 62.7 years; 49.1% women) participants were included. Compared with nonsmokers, smokers had a higher CH (UKB, +0.48 mm Hg; CLSA, +0.57 mm Hg; P < 0.001) and corneal resistance factor (UKB, +0.47 mm Hg; CLSA, +0.60 mm Hg; P < 0.001) with evidence of a dose-response effect in both studies. Differential associations with Goldmann-correlated IOP (UKB, +0.25 mm Hg; CLSA, +0.36 mm Hg; P < 0.001) and corneal-compensated IOP (UKB, -0.28 mm Hg; CLSA, -0.32 mm Hg; P ≤ 0.001) were observed. Smoking was not associated with inner retinal thicknesses or glaucoma status in either study. MR provided evidence for a causal effect of smoking on corneal biomechanics, especially higher CH. CONCLUSIONS: Cigarette smoking seems to increase corneal biomechanical resistance to deformation, but there was little evidence to support a relationship with glaucoma. This outcome may result in an artefactual association with measured IOP and could account for discordant results with glaucoma in previous epidemiological studies.

Type: Article
Title: Smoking, Corneal Biomechanics, and Glaucoma: Results From Two Large Population-Based Cohorts
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/iovs.65.1.11
Publisher version: http://dx.doi.org/10.1167/iovs.65.1.11
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10185027
Downloads since deposit
5Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item