UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations

Liu, D; Meyer, D; Fennessy, B; Feng, C; Cheng, E; Johnson, JS; Park, YJ; ... Reichenberg, A; + view all (2023) Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics , 55 (3) pp. 369-376. 10.1038/s41588-023-01305-1. Green open access

[thumbnail of s41588-023-01305-1.pdf]
Preview
PDF
s41588-023-01305-1.pdf - Published Version

Download (1MB) | Preview

Abstract

Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes1. This recent study—and most other large-scale human genetics studies—was mainly composed of individuals of European (EUR) ancestry, and the generalizability of the findings in non-EUR populations remains unclear. To address this gap, we designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of diverse ancestries. Replicating earlier work, we found that cases carried a significantly higher burden of rare protein-truncating variants (PTVs) among evolutionarily constrained genes (odds ratio = 1.48; P = 5.4 × 10−6). In meta-analyses with existing datasets totaling up to 35,828 cases and 107,877 controls, this excess burden was largely consistent across five ancestral populations. Two genes (SRRM2 and AKAP11) were newly implicated as SCZ risk genes, and one gene (PCLO) was identified as shared by individuals with SCZ and those with autism. Overall, our results lend robust support to the rare allelic spectrum of the genetic architecture of SCZ being conserved across diverse human populations.

Type: Article
Title: Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41588-023-01305-1
Publisher version: http://dx.doi.org/10.1038/s41588-023-01305-1
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Humans, Schizophrenia, Autistic Disorder, Alleles, Genetic Predisposition to Disease, Genome-Wide Association Study
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10184868
Downloads since deposit
6Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item