Garfield, Victoria;
Anderson, Emma L;
(2024)
A brief comparison of polygenic risk scores and Mendelian randomisation.
BMC Medical Genomics
, 17
(1)
, Article 10. 10.1186/s12920-023-01769-4.
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Abstract
Mendelian randomisation and polygenic risk score analysis have become increasingly popular in the last decade due to the advent of large-scale genome-wide association studies. Each approach has valuable applications, some of which are overlapping, yet there are important differences which we describe here.
| Type: | Article |
|---|---|
| Title: | A brief comparison of polygenic risk scores and Mendelian randomisation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s12920-023-01769-4 |
| Publisher version: | http://dx.doi.org/10.1186/s12920-023-01769-4 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Mendelian randomisation, Polygenic risk scores, Genome-wide association studies, Horizontal pleiotropy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health of Older People |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10184707 |
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