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Social scientists would do well to steer clear of polygenic scores

Curtis, David; (2023) Social scientists would do well to steer clear of polygenic scores. Behavioral and Brain Sciences , 46 , Article e212. 10.1017/S0140525X22002448. Green open access

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Abstract

The problems with polygenic scores (PGSs) have been understated. The fact that they are ancestry-specific means that biases related to sociodemographic factors would be impossible to avoid. Additionally, the requirement to obtain DNA would have profound impacts on study design and required resources, as well as likely introducing recruitment bias. PGSs are unhelpful for social science research.

Type: Article
Title: Social scientists would do well to steer clear of polygenic scores
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0140525X22002448
Publisher version: http://dx.doi.org/10.1017/s0140525x22002448
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10184546
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