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Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children

Maghsoudlou, P; Abraham, AR; El-Ashry, M; Chew, C; Mohd, N; Ramanan, AV; Dick, AD; (2023) Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children. Ocular Immunology and Inflammation , 31 (10) pp. 1930-1943. 10.1080/09273948.2023.2282610. Green open access

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Abstract

Monogenic autoinflammatory syndromes (MAISs), are caused by pathogenic genetic variants in the innate immune system, leading to dysregulation and aberrant inflammasome activation spontaneously or with minimal triggering. The diagnosis and treatment of MAISs can be intricate, relying on an increased recognition of potential differential diagnoses. This review examines the clinical features of MAIS, with a special focus on uveitis. It also evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.

Type: Article
Title: Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/09273948.2023.2282610
Publisher version: http://dx.doi.org/10.1080/09273948.2023.2282610
Language: English
Additional information: © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Autoinflammation, cytokine, inflammasome, inflammation, uveitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10184293
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