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Underrepresentation of ethnic minorities in UK COVID-19 trials: comment on a recent systematic review and meta-analysis

Ersoy Guller, Zeynep; Green, Frederick; Goodman, Anna L; (2023) Underrepresentation of ethnic minorities in UK COVID-19 trials: comment on a recent systematic review and meta-analysis. BMC Medicine , 21 , Article 308. 10.1186/s12916-023-03002-6. Green open access

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Abstract

During the Coronavirus disease (COVID-19) pandemic, clinical trials investigating potential vaccines and therapeutics have led to incredible breakthroughs and greatly improved outcomes; however, there have been growing concerns regarding the underrepresentation of ethnic minorities among trial participants [1]. This is concerning for two primary reasons. First is to ensure that trial interventions are actually effective in the target population, with COVID-19 known to disproportionately affect ethnic minorities [2]. Second is a lack of representation fuels mistrust in clinical trials [3], which may lead to vaccine hesitancy in minority communities, resulting in worse outcomes from COVID-19 infection. A recent systematic review and meta-analysis by Murali et al. in BMC Medicine [4] revealed an underrepresentation of ethnic minorities in UK-based COVID-19 clinical trials and made suggestions to help improve ethnic minority representation in future trials.

Type: Article
Title: Underrepresentation of ethnic minorities in UK COVID-19 trials: comment on a recent systematic review and meta-analysis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s12916-023-03002-6
Publisher version: https://doi.org/10.1186/s12916-023-03002-6
Language: English
Additional information: © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data
Keywords: COVID-19, Ethnicity, Diversity, Clinical trials, Medical research
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10184118
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