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Advanced Applications of Silk-Based Hydrogels for Tissue Engineering: A Short Review

Akdag, Zekiye; Ulag, Songul; Kalaskar, Deepak M; Duta, Liviu; Gunduz, Oguzhan; (2023) Advanced Applications of Silk-Based Hydrogels for Tissue Engineering: A Short Review. Biomimetics , 8 (8) , Article 612. 10.3390/biomimetics8080612. Green open access

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Abstract

Silk has been consistently popular throughout human history due to its enigmatic properties. Today, it continues to be widely utilized as a polymer, having first been introduced to the textile industry. Furthermore, the health sector has also integrated silk. The Bombyx mori silk fibroin (SF) holds the record for being the most sustainable, functional, biocompatible, and easily produced type among all available SF sources. SF is a biopolymer approved by the FDA due to its high biocompatibility. It is versatile and can be used in various fields, as it is non-toxic and has no allergenic effects. Additionally, it enhances cell adhesion, adaptation, and proliferation. The use of SF has increased due to the rapid advancement in tissue engineering. This review comprises an introduction to SF and an assessment of the relevant literature using various methods and techniques to enhance the tissue engineering of SF-based hydrogels. Consequently, the function of SF in skin tissue engineering, wound repair, bone tissue engineering, cartilage tissue engineering, and drug delivery systems is therefore analysed. The potential future applications of this functional biopolymer for biomedical engineering are also explored.

Type: Article
Title: Advanced Applications of Silk-Based Hydrogels for Tissue Engineering: A Short Review
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/biomimetics8080612
Publisher version: https://doi.org/10.3390/biomimetics8080612
Language: English
Additional information: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: silk-based hydrogels; tissue engineering; wound repair; drug delivery; biomimetics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10184097
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