UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Protocol for potential energy-based bifurcation analysis, parameter searching, and phase diagram analysis of noncanonical bistable switches

Barik, D; Das, S; (2023) Protocol for potential energy-based bifurcation analysis, parameter searching, and phase diagram analysis of noncanonical bistable switches. STAR Protocols , 4 (4) , Article 102665. 10.1016/j.xpro.2023.102665. Green open access

[thumbnail of 1-s2.0-S2666166723006329-main.pdf]
Preview
PDF
1-s2.0-S2666166723006329-main.pdf - Published Version

Download (4MB) | Preview

Abstract

We have explored the design principles of noncanonical bistable switches using high-throughput bifurcation analysis of positive feedback loops under dual signaling. Here, we present a protocol to carry out bifurcation analysis using pseudo-potential energy of the dynamical system. We also describe steps to perform automated parameter searching for canonical and noncanonical switches and multi-parameter phase diagram analysis of these switches. For complete details on the use and execution of this protocol, please refer to Das et al.1

Type: Article
Title: Protocol for potential energy-based bifurcation analysis, parameter searching, and phase diagram analysis of noncanonical bistable switches
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.xpro.2023.102665
Publisher version: https://doi.org/10.1016/j.xpro.2023.102665
Language: English
Additional information: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Biophysics, Biotechnology and Bioengineering, Computer Sciences, Systems Biology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10183916
Downloads since deposit
3Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item