Montesano, G;
Redmond, T;
Mulholland, PJ;
Garway-Heath, DF;
Ometto, G;
Romano, D;
Antonacci, F;
... Oddone, F; + view all
(2023)
Spatial Summation in the Glaucomatous Macula: A Link With Retinal Ganglion Cell Damage.
Investigative Ophthalmology & Visual Science
, 64
(36)
10.1167/iovs.64.14.36.
Preview |
PDF
i1552-5783-64-14-36_1700652658.5152.pdf - Published Version Download (7MB) | Preview |
Abstract
Purpose: The purpose of this study was to test whether functional loss in the glaucomatous macula is characterized by an enlargement of Ricco's area (RA) through the application of a computational model linking retinal ganglion cell (RGC) damage to perimetric sensitivity. Methods: One eye from each of 29 visually healthy subjects <40 years old, 30 patients with glaucoma, and 20 age-similar controls was tested with a 10-2 grid with stimuli of 5 different area sizes. Structural estimates of point-wise RGC density were obtained from optical coherence tomography (OCT) scans. Structural and functional data from the young healthy cohort were used to estimate the parameters of a computational spatial summation model to generate a template. The template was fitted with a Bayesian hierarchical model to estimate the latent RGC density in patients with glaucoma and age-matched controls. We tested two alternative hypotheses: fitting the data by translating the template horizontally (H1: change in RA) or vertically (H2: loss of sensitivity without a change in RA). Root mean squared error (RMSE) of the model fits to perimetric sensitivity were compared. Ninety-five percent confidence intervals were bootstrapped. The dynamic range of the functional and structural RGC density estimates was denoted by their 1st and 99th percentiles. Results: The RMSE was 2.09 (95% CI = 1.92–2.26) under H1 and 2.49 (95% CI = 2.24–2.72) under H2 (P < 0.001). The average dynamic range for the structural RGC density estimates was only 11% that of the functional estimates. Conclusions: Macular sensitivity loss in glaucoma is better described by a model in which RA changes with RGC loss. Structural measurements have limited dynamic range.
| Type: | Article |
|---|---|
| Title: | Spatial Summation in the Glaucomatous Macula: A Link With Retinal Ganglion Cell Damage |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1167/iovs.64.14.36 |
| Publisher version: | https://doi.org/10.1167/iovs.64.14.36 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Keywords: | Adult, Humans, Bayes Theorem, Glaucoma, Retinal Ganglion Cells, Tomography, Optical Coherence, Visual Field Tests, Visual Fields, Macular Degeneration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10183879 |
Archive Staff Only
 |
View Item |
