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Genomics enabling personalised glaucoma care

Stuart, Kelsey V; Khawaja, Anthony P; (2023) Genomics enabling personalised glaucoma care. British Journal of Ophthalmology 10.1136/bjo-2023-324618. (In press). Green open access

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Abstract

Glaucoma is a leading cause of visual impairment and a significant public health concern, but despite ongoing advances in our understanding of the disease, several important clinical challenges remain. With the number of affected people projected to increase substantially over coming decades, novel approaches to screening, risk stratification, therapy and glaucoma research are essential to deal with this expanding burden in an efficient and cost-effective manner. Genomics may hold the key to unlocking further biological insights and enabling precision medicine, in which glaucoma care is tailored to the individual patient, based on their unique profile for disease. Here, we provide an overview of how genomics may enable cost-effective targeted population screening and personalised predictions of risk, response to treatment and effective lifestyle advice. Given rapid advances in genetic testing technology and a move towards population-level genotyping, these early results have several important implications that promise to revolutionise the way in which glaucoma is detected and managed in years to come.

Type: Article
Title: Genomics enabling personalised glaucoma care
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bjo-2023-324618
Publisher version: https://doi.org/10.1136/bjo-2023-324618
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Epidemiology, Genetics, Glaucoma, Intraocular pressure
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10183725
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