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Plastic persisters: revival stem cells in colorectal cancer

Tape, Christopher J; (2023) Plastic persisters: revival stem cells in colorectal cancer. Trends in Cancer 10.1016/j.trecan.2023.11.003. (In press). Green open access

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Abstract

Colorectal cancer (CRC) is traditionally considered to be a genetically driven disease. However, nongenetic plasticity has recently emerged as a major driver of tumour initiation, metastasis, and therapy response in CRC. Central to these processes is a recently discovered cell type, the revival colonic stem cell (revCSC). In contrast to traditional proliferative CSCs (proCSCs), revCSCs prioritise survival over propagation. revCSCs play an essential role in primary tumour formation, metastatic dissemination, and nongenetic chemoresistance. Current evidence suggests that CRC tumours leverage intestinal stem cell plasticity to both proliferate (via proCSCs) when unchallenged and survive (via revCSCs) in response to cell-extrinsic pressures. Although revCSCs likely represent a major source of therapeutic failure in CRC, our increasing knowledge of this important stem cell fate provides novel opportunities for therapeutic intervention.

Type: Article
Title: Plastic persisters: revival stem cells in colorectal cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trecan.2023.11.003
Publisher version: https://doi.org/10.1016/j.trecan.2023.11.003
Language: English
Additional information: Copyright © 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Colorectal cancer (CRC); revival stem cells; metastasis; drug-tolerant persister (DTP); plasticity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10183520
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