Chen, Lawrence M;
Pokhvisneva, Irina;
Lahti-Pulkkinen, Marius;
Kvist, Tuomas;
Baldwin, Jessie R;
Parent, Carine;
Silveira, Patricia P;
... O'Donnell, Kieran J; + view all
(2023)
Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores.
Journal of the American Academy of Child and Adolescent Psychiatry
10.1016/j.jaac.2023.08.018.
(In press).
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Abstract
OBJECTIVE: Prenatal maternal symptoms of depression and anxiety associate with an increased risk for child socioemotional and behavioral difficulties, supporting the fetal origins of mental health hypothesis. However, to date, studies have not considered specific genomic risk as a possible confound. METHOD: We used the Avon Longitudinal Study of Parents and Children (n=5,546) to test if child polygenic risk for attention-deficit hyperactivity disorder (ADHD), schizophrenia, or depression confounds or modifies the impact of prenatal maternal depression and anxiety on child internalizing, externalizing, and total emotional/behavioral symptoms from 4-16 years. We analyzed longitudinal child/adolescent symptom data using generalized estimating equations (GEE) in the ALSPAC cohort. Replication analyses were carried out in an independent cohort (PREDO n=514) from Finland, which provided complementary measures of maternal mental health, and child psychiatric symptoms (n=514). RESULTS: Maternal depression and anxiety and child genomic polygenic risk independently and additively predicted behavioral and emotional symptoms from childhood through mid-adolescence. There was a robust prediction of child/adolescent symptoms from both prenatal maternal depression (GEE Est.=0.096, 95% CI: 0.065-0.121, p=2.66E-10) and anxiety (GEE Est.=0.065, 95% CI: 0.037-0.093, p=1.62E-05) after adjusting for child genomic risk for mental disorders. There was a similar independent effect of maternal depression (B=0.156, 95% CI: 0.066-0.246, p=0.001) on child symptoms in the PREDO cohort. Genetically informed sensitivity analyses suggest that shared genetic risk only partially explains the reported association between prenatal maternal depression and offspring mental health. CONCLUSION: These findings highlight the genomic contribution to the fetal origins of mental health hypothesis and further evidence that prenatal maternal depression and anxiety are robust in utero risks for child/adolescent psychiatric symptoms.
| Type: | Article |
|---|---|
| Title: | Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jaac.2023.08.018 |
| Publisher version: | https://doi.org/10.1016/j.jaac.2023.08.018 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | ALSPAC, Child Development, Fetal Origins of Mental Health, Maternal Depression, Polygenic Risk Score |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10183470 |
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