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Microfocus computed tomography for fetal postmortem imaging: an overview

Docter, Daniel; Dawood, Yousif; Jacobs, Karl; Hagoort, Jaco; Oostra, Roelof-Jan; van den Hoff, Maurice JB; Arthurs, Owen J; (2022) Microfocus computed tomography for fetal postmortem imaging: an overview. Pediatric Radiology , 53 (4) pp. 632-639. 10.1007/s00247-022-05517-1. Green open access

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Abstract

Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically challenging and is often unaccepted by parents. This article provides an overview of the latest research in fetal postmortem micro-CT imaging with a focus on diagnostic accuracy, endovascular staining approaches, placental studies and the reversibility of staining. It also discusses new methods that could prove helpful for micro-CT of larger fetuses. While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens.

Type: Article
Title: Microfocus computed tomography for fetal postmortem imaging: an overview
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00247-022-05517-1
Publisher version: https://doi.org/10.1007/s00247-022-05517-1
Language: English
Additional information: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology, Life Sciences & Biomedicine, Pediatrics, Radiology, Nuclear Medicine & Medical Imaging, Anatomy, Autopsy, Diffusible iodine-based contrast-enhanced computed tomography, Fetus, Human, Intrauterine fetal demise, Microfocus computed tomography, Postmortem, Stillbirth, MICROCOMPUTED TOMOGRAPHY, CT, VASCULATURE, PERFUSION, MICROCT, IODINE, HEART, TOOL
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10183447
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