UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium

Alonso-Carriazo Fernandez, Ana; Butt, Zaynab; Foster, Evangeline; Carr, Amanda-Jayne; (2023) A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium. The Biochemist pp. 1-5. 10.1042/bio_2023_147. (In press). Green open access

[thumbnail of bio_2023_147.pdf]
Preview
PDF
bio_2023_147.pdf - Published Version

Download (967kB) | Preview

Abstract

Macular diseases are one of the leading causes of vision loss in the western world. In the UK alone, almost 1.5 million people suffer from these devastating diseases, which primarily affect the macula, a region in the retina responsible for detailed central vision. In many patients, cellular changes, attributable to ageing or inherited mutations, are associated with the retinal pigment epithelium (RPE), a single layer of cells that sustains and supports the light-sensitive retina. In the absence of functional RPE, the retina becomes damaged and vision deteriorates. Currently, there are no treatments for these diseases. Over the last two decades, induced pluripotent stem cells have revolutionized our study of retinal disorders, enabling researchers to produce previously inaccessible RPE cells in a dish. The ability to recreate these cells from patients has provided new model systems to understand the mechanisms behind the disease and accelerate the development of new therapies to treat sight loss.

Type: Article
Title: A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/bio_2023_147
Publisher version: https://doi.org/10.1042/bio_2023_147
Language: English
Additional information: © The Authors. Published by Portland Press Limited under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10182855
Downloads since deposit
17Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item