UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy

Lange, F; Verma, V; Harvey-Jones, K; Mitra, S; Tachtsidis, I; (2023) Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy. Advances in Experimental Medicine and Biology , 1438 pp. 167-172. 10.1007/978-3-031-42003-0_26.

[thumbnail of LANGE_ISOTT2022_revisedClean.pdf] Text
LANGE_ISOTT2022_revisedClean.pdf - Accepted Version
Access restricted to UCL open access staff until 18 October 2024.

Download (338kB)

Abstract

We present here the initial development of a novel algorithm based on broadband near-infrared spectroscopy (bNIRS) data to estimate the changes in brain temperature (BT) in neonates. We first explored the validity of the methodology on a simple numerical phantom and reported good agreements between the theoretical and retrieved values of BT and hemodynamic parameters changes, which are the parameters usually targeted by bNIRS. However, we noted an underestimation of the absolute values of temperature and haemoglobins' concentration changes when large variations of tissue saturation were induced, probably due to a crosstalk between the species in this specific case. We then tested this methodology on data acquired on 2 piglets during a protocol that induces seizures. We showed that despite a decrease in rectal temperature (RT) over time (-0.1048 °C 1.5 h after seizure induction, 95% CI: -0.1035 to -0.1061 °C), BT was raising (0.3122 °C 1.5 h after seizure induction, 95% CI: 0.3207 to 0.3237 °C). We also noted that the piglet displaying the largest decrease in RT also displays the highest increase in BT, which could be a marker of the severity of the seizure induced brain injury. These initial results are encouraging and show that having access to the changes in BT non-invasively could help to better understand the impact of BT on injury severity and to improve the current cooling methodologies in the neonatal neurocritical care following neonatal encephalopathy.

Type: Article
Title: Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy
Location: United States
DOI: 10.1007/978-3-031-42003-0_26
Publisher version: https://doi.org/10.1007/978-3-031-42003-0_26
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Brain temperature, Broadband near-infrared spectroscopy, Neonates, Neuromonitoring
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
URI: https://discovery.ucl.ac.uk/id/eprint/10182821
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item