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A practical approach to refractory Kawasaki disease

Riyad, C; Brogan, P; (2022) A practical approach to refractory Kawasaki disease. Paediatrics and Child Health , 32 (12) pp. 476-479. 10.1016/j.paed.2022.10.005. Green open access

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Abstract

Kawasaki disease (KD) is a medium vessel vasculitis and is the most common cause of acquired heart disease in childhood. If left untreated, KD leads to coronary artery aneurysms in 15–25% of patients and the mortality rate in the UK is currently 0.4%. As such, KD is an important preventable cause of heart disease in the young. The aetiology of KD remains unknown, but most likely it represents an aberrant inflammatory host response to one or more as yet unidentified immunological trigger(s) in genetically predisposed individuals. The purpose of this article is not to provide an exhaustive review of KD. Rather we provide practical guidance to the clinical approach to refractory KD. Only brief background on the pathogenesis and epidemiology of KD, and emerging newer clinical trials is provided, to place our clinical approach in context.

Type: Article
Title: A practical approach to refractory Kawasaki disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.paed.2022.10.005
Publisher version: https://doi.org/10.1016/j.paed.2022.10.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Coronary artery aneurysm, glucocorticoids, IVIG resistance, Kawasaki disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10182563
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