Holden, Clare J;
Lampe, Fiona C;
Burns, Fiona M;
Chaloner, Clinton;
Johnson, Margaret;
Kinloch-De Loes, Sabine;
Smith, Colette J;
(2024)
Association of age at antiretroviral therapy initiation with CD4⁺ : CD8⁺ ratio recovery among virally suppressed people with HIV.
AIDS
, 38
(5)
pp. 703-711.
10.1097/QAD.0000000000003801.
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Abstract
OBJECTIVE: To investigate the association of age at anti-retroviral therapy (ART) initiation with CD4:CD8 T cell ratio in virally suppressed people with HIV on long-term ART, and to characterize potential CD4:CD8 ratio recovery in this population by age. DESIGN: A longitudinal study of people attending an HIV clinic at the Royal Free Hospital NHS Trust, London, who initiated ART between 2001 and 2015, and achieved and maintained HIV-1 viral suppression (VL<100 c/mL). The association of age group at ART initiation with CD4:CD8 ratio at 5 and 10 years was assessed. METHODS: Multivariable linear regression was used to investigate the relationship between age at ART initiation and log CD4:CD8 ratio, adjusting for demographic factors (gender/HIV transmission route, ethnicity), baseline CD4 count and calendar year. RESULTS: The sample included 1859 people aged 20-78 (75% male, 56% white ethnicity). Overall, median CD4:CD8 T cell ratio increased from 0.24 at baseline to 0.77 at year 5 and 0.88 at year 10. Ratios increased among all age groups in unadjusted and adjusted models but increased less among older ages (baseline ages 60-69 and 70-79). Median ratios at year 5 were 0.85, 0.80, 0.72, 0.76, 0.6 and 0.44 respectively among people aged 20-29, 30-39, 40-49, 50-59, 60-69 and 70-79 years at baseline. CONCLUSIONS: In a virally suppressed London population, age had a substantial impact on CD4:CD8 ratio recovery, especially for those starting ART after age 60. Results may indicate the level of CD4:CD8 ratio recovery possible in an HIV positive, virally suppressed, aging population.
| Type: | Article |
|---|---|
| Title: | Association of age at antiretroviral therapy initiation with CD4⁺ : CD8⁺ ratio recovery among virally suppressed people with HIV |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/QAD.0000000000003801 |
| Publisher version: | http://doi.org/10.1097/QAD.0000000000003801 |
| Language: | English |
| Additional information: | This is an Open Access article published under a Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Aging; antiretroviral therapy; CD4:CD8 ratio; HIV |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10182498 |
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