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Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality

Bettinger, Jesse S; Friston, Karl J; (2023) Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality. Neuroscience & Biobehavioral Reviews , 155 , Article 105459. 10.1016/j.neubiorev.2023.105459. Green open access

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Abstract

Bettinger, J. S., K. J. Friston. Conceptual Foundations of Physiological Regulation incorporating the Free Energy Principle & Self-Organized Criticality. NEUROSCI BIOBEHAV REV 23(x) 144-XXX, 2022. Since the late nineteen-nineties, the concept of homeostasis has been contextualized within a broader class of "allostatic" dynamics characterized by a wider-berth of causal factors including social, psychological and environmental entailments; the fundamental nature of integrated brain-body dynamics; plus the role of anticipatory, top-down constraints supplied by intrinsic regulatory models. Many of these evidentiary factors are integral in original descriptions of homeostasis; subsequently integrated; and/or cite more-general operating principles of self-organization. As a result, the concept of allostasis may be generalized to a larger category of variational systems in biology, engineering and physics in terms of advances in complex systems, statistical mechanics and dynamics involving heterogenous (hierarchical/heterarchical, modular) systems like brain-networks and the internal milieu. This paper offers a three-part treatment. 1) interpret "allostasis" to emphasize a variational and relational foundation of physiological stability; 2) adapt the role of allostasis as "stability through change" to include a "return to stability" and 3) reframe the model of homeostasis with a conceptual model of criticality that licenses the upgrade to variational dynamics.

Type: Article
Title: Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2023.105459
Publisher version: https://doi.org/10.1016/j.neubiorev.2023.105459
Language: English
Additional information: © 2023 The Authors. Published by Elsevier Ltd. under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Keywords: Physiological regulation, Homeostasis, Allostasis, Variational systems, Free energy principle, Criticality, Griffiths region, Complex adaptive systems, Dynamic stability, Metastability, Control theory, Neuro-immunology, Computational psychiatry, Resilience
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10182419
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