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Enabling the evaluation of COVID-19 vaccines with correlates of protection

Marchant, Arnaud; Van Damme, Pierre; Plotkin, Stanley; Neels, Pieter; Cassetti, Maria Cristina; Cramer, Jakob; Gruber, Marion F; ... Vandeputte, Joris; + view all (2024) Enabling the evaluation of COVID-19 vaccines with correlates of protection. Biologicals , 85 , Article 101723. 10.1016/j.biologicals.2023.101723. Green open access

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Abstract

In February 2023, a meeting about correlates of protection (CoPs) against COVID-19 was organized by the International Alliance for Biological Standardization, the European Plotkin Institute for Vaccinology, and Vaccinopolis. The meeting aimed at reviewing the evidence, drawing conclusions, and identifying knowledge gaps. Collection of evidence is not straightforward. Neutralizing antibodies correlate with protection and are used for immunobridging studies within and between vaccine platforms for approval of new COVID-19 vaccines. In preparation for the next pandemic, it is vital that rapidly authorized initial vaccines are available to perform immunobridging studies very early. Additional components of the immune response likely contribute to protection against symptomatic infection. Current evidence is strongest for T lymphocytes and binding antibodies. Further studies are needed to consolidate this evidence and define their potential role in the evaluation of vaccines. For evaluation of mucosal vaccines, identifying CoPs against infection and transmission is key; further research is needed to identify and standardize methods suitable for clinical studies. CoPs for broadly protective beta-coronavirus vaccines remain a critical area of research. The knowledge, expertise, and capacity exist to conduct clinical studies using different designs in different populations to discover and validate CoPs, facilitating and accelerating evaluation of novel vaccines/vaccination platforms.

Type: Article
Title: Enabling the evaluation of COVID-19 vaccines with correlates of protection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biologicals.2023.101723
Publisher version: https://doi.org/10.1016/j.biologicals.2023.101723
Language: English
Additional information: Copyright © 2023 Published by Elsevier Ltd on behalf of International Alliance for Biological Standardization. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: COVID-19; SARS-CoV-2; Correlate of protection; Biomarker; Immune marker; International alliance for biological standardization
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10182388
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