UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Glaucoma: now and beyond

Jayaram, Hari; Kolko, Miriam; Friedman, David S; Gazzard, Gus; (2023) Glaucoma: now and beyond. The Lancet , 402 (10414) pp. 1788-1801. 10.1016/S0140-6736(23)01289-8.

[thumbnail of Gazzard_Lancet Seminar_161022 (SUBMITTED VERSION).pdf] Text
Gazzard_Lancet Seminar_161022 (SUBMITTED VERSION).pdf
Access restricted to UCL open access staff until 10 May 2024.

Download (747kB)

Abstract

The glaucomas are a group of conditions leading to irreversible sight loss and characterised by progressive loss of retinal ganglion cells. Although not always elevated, intraocular pressure is the only modifiable risk factor demonstrated by large clinical trials. It remains the leading cause of irreversible blindness, but timely treatment to lower intraocular pressure is effective at slowing the rate of vision loss from glaucoma. Methods for lowering intraocular pressure include laser treatments, topical medications, and surgery. Although modern surgical innovations aim to be less invasive, many have been introduced with little supporting evidence from randomised controlled trials. Many cases remain undiagnosed until the advanced stages of disease due to the limitations of screening and poor access to opportunistic case finding. Future research aims to generate evidence for intraocular pressure-independent neuroprotective treatments, personalised treatment through genetic risk profiling, and exploration of potential advanced cellular and gene therapies.

Type: Article
Title: Glaucoma: now and beyond
Location: England
DOI: 10.1016/S0140-6736(23)01289-8
Publisher version: https://doi.org/10.1016/S0140-6736(23)01289-8
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Humans, Glaucoma, Open-Angle, Glaucoma, Intraocular Pressure, Blindness, Vision Disorders
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10181777
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item