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Exosomes Interactions with the Blood-Brain Barrier: Implications for Cerebral Disorders and Therapeutics

Osaid, Zaynab; Haider, Mohamed; Hamoudi, Rifat; Harati, Rania; (2023) Exosomes Interactions with the Blood-Brain Barrier: Implications for Cerebral Disorders and Therapeutics. International Journal of Molecular Sciences , 24 (21) , Article 15635. 10.3390/ijms242115635. Green open access

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Abstract

The Blood-Brain Barrier (BBB) is a selective structural and functional barrier between the circulatory system and the cerebral environment, playing an essential role in maintaining cerebral homeostasis by limiting the passage of harmful molecules. Exosomes, nanovesicles secreted by virtually all cell types into body fluids, have emerged as a major mediator of intercellular communication. Notably, these vesicles can cross the BBB and regulate its physiological functions. However, the precise molecular mechanisms by which exosomes regulate the BBB remain unclear. Recent research studies focused on the effect of exosomes on the BBB, particularly in the context of their involvement in the onset and progression of various cerebral disorders, including solid and metastatic brain tumors, stroke, neurodegenerative, and neuroinflammatory diseases. This review focuses on discussing and summarizing the current knowledge about the role of exosomes in the physiological and pathological modulation of the BBB. A better understanding of this regulation will improve our understanding of the pathogenesis of cerebral diseases and will enable the design of effective treatment strategies.

Type: Article
Title: Exosomes Interactions with the Blood-Brain Barrier: Implications for Cerebral Disorders and Therapeutics
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/ijms242115635
Publisher version: https://doi.org/10.3390/ijms242115635
Language: English
Additional information: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: Blood–Brain Barrier (BBB), brain tumors, exosomes, extra cellular vesicles (EV), neurodegenerative diseases, neuroinflammation, neurovascular unit (NVU), Humans, Blood-Brain Barrier, Exosomes, Stroke, Brain Neoplasms, Neuromuscular Diseases
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10181626
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