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Brain organoids for hypoxic-ischemic studies: from bench to bedside

Gaston-Breton, R; Maïza Letrou, A; Hamoudi, R; Stonestreet, BS; Mabondzo, A; (2023) Brain organoids for hypoxic-ischemic studies: from bench to bedside. Cellular and Molecular Life Sciences , 80 (11) , Article 318. 10.1007/s00018-023-04951-0. Green open access

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Abstract

Our current knowledge regarding the development of the human brain mostly derives from experimental studies on non-human primates, sheep, and rodents. However, these studies may not completely simulate all the features of human brain development as a result of species differences and variations in pre- and postnatal brain maturation. Therefore, it is important to supplement the in vivo animal models to increase the possibility that preclinical studies have appropriate relevance for potential future human trials. Three-dimensional brain organoid culture technology could complement in vivo animal studies to enhance the translatability of the preclinical animal studies and the understanding of brain-related disorders. In this review, we focus on the development of a model of hypoxic-ischemic (HI) brain injury using human brain organoids to complement the translation from animal experiments to human pathophysiology. We also discuss how the development of these tools provides potential opportunities to study fundamental aspects of the pathophysiology of HI-related brain injury including differences in the responses between males and females.

Type: Article
Title: Brain organoids for hypoxic-ischemic studies: from bench to bedside
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00018-023-04951-0
Publisher version: https://doi.org/10.1007/s00018-023-04951-0
Language: English
Additional information: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: 3D technology, Hypoxic-ischemic encephalopathy, Therapeutic trials, Translational research, Male, Female, Animals, Humans, Sheep, Disease Models, Animal, Brain, Hypoxia-Ischemia, Brain, Rodentia, Organoids, Brain Injuries
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10181625
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