Fernandes, Guilherme FS;
Lopes, Juliana R;
Dos Santos, Jean L;
Scarim, Cauê B;
(2023)
Phthalimide as a versatile pharmacophore scaffold: Unlocking its diverse biological activities.
Drug Development Research
, 84
(7)
pp. 1346-1375.
10.1002/ddr.22094.
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Abstract
Phthalimide, a pharmacophore exhibiting diverse biological activities, holds a prominent position in medicinal chemistry. In recent decades, numerous derivatives of phthalimide have been synthesized and extensively studied for their therapeutic potential across a wide range of health conditions. This comprehensive review highlights the latest developments in medicinal chemistry, specifically focusing on phthalimide-based compounds that have emerged within the last decade. These compounds showcase promising biological activities, including anti-inflammatory, anti-Alzheimer, antiepileptic, antischizophrenia, antiplatelet, anticancer, antibacterial, antifungal, antimycobacterial, antiparasitic, anthelmintic, antiviral, and antidiabetic properties. The physicochemical profiles of the phthalimide derivatives were carefully analyzed using the online platform pkCSM, revealing the remarkable versatility of this scaffold. Therefore, this review emphasizes the potential of phthalimide as a valuable scaffold for the development of novel therapeutic agents, providing avenues for the exploration and design of new compounds.
Type: | Article |
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Title: | Phthalimide as a versatile pharmacophore scaffold: Unlocking its diverse biological activities |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1002/ddr.22094 |
Publisher version: | https://doi.org/10.1002/ddr.22094 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Bioactive compounds; drug design; medicinal chemistry; new drugs; phthalimide; thalidomide |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
URI: | https://discovery.ucl.ac.uk/id/eprint/10181506 |
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