UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Immune-neuroendocrine patterning and response to stress. A latent profile analysis in the English longitudinal study of ageing

Hamilton, Odessa S; Iob, Eleonora; Ajnakina, Olesya; Kirkbride, James B; Steptoe, Andrew; (2023) Immune-neuroendocrine patterning and response to stress. A latent profile analysis in the English longitudinal study of ageing. Brain, Behavior, and Immunity 10.1016/j.bbi.2023.11.012. (In press). Green open access

[thumbnail of 1-s2.0-S0889159123003458-main.pdf]
Preview
Text
1-s2.0-S0889159123003458-main.pdf - Accepted Version

Download (522kB) | Preview

Abstract

Psychosocial stress exposure can disturb communication signals between the immune, nervous, and endocrine systems that are intended to maintain homeostasis. This dysregulation can provoke a negative feedback loop between each system that has high pathological risk. Here, we explore patterns of immune-neuroendocrine activity and the role of stress. Using data from the English Longitudinal Study of Ageing (ELSA), we first identified the latent structure of immune-neuroendocrine activity (indexed by high sensitivity C-reactive protein [CRP], fibrinogen [Fb], hair cortisol [cortisol], and insulin growth-factor-1 [IGF-1]), within a population-based cohort using latent profile analysis (LPA). Then, we determined whether life stress was associated with membership of different immune-neuroendocrine profiles. We followed 4,934 male and female participants with a median age of 65 years over a four-year period (2008–2012). A three-class LPA solution offered the most parsimonious fit to the underlying immune-neuroendocrine structure in the data, with 36 %, 40 %, and 24 % of the population belonging to profiles 1 (low-risk), 2 (moderate-risk), and 3 (high-risk), respectively. After adjustment for genetic predisposition, sociodemographics, lifestyle, and health, higher exposure to stress was associated with a 61 % greater risk of belonging to the high-risk profile (RRR: 1.61; 95 %CI = 1.23–2.12, p = 0.001), but not the moderate-risk profile (RRR = 1.10, 95 %CI = 0.89–1.35, p = 0.401), as compared with the low-risk profile four years later. Our findings extend existing knowledge on psychoneuroimmunological processes, by revealing how inflammation and neuroendocrine activity cluster in a representative sample of older adults, and how stress exposure was associated with immune-neuroendocrine responses over time.

Type: Article
Title: Immune-neuroendocrine patterning and response to stress. A latent profile analysis in the English longitudinal study of ageing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbi.2023.11.012
Publisher version: https://doi.org/10.1016/j.bbi.2023.11.012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Stress, Inflammation, Immune, Neuroendocrine activity, Longitudinal, Latent Profile analysis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Mental Health Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10181456
Downloads since deposit
43Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item