Kasza, Karolina;
Elsherbeny, Amr;
Moloney, Cara;
Hardie, Kim R;
Cámara, Miguel;
Alexander, Cameron;
Gurnani, Pratik;
(2023)
Hybrid Poly(<i>β</i>‐amino ester) Triblock Copolymers Utilizing a RAFT Polymerization Grafting‐From Methodology.
Macromolecular Chemistry and Physics
10.1002/macp.202300262.
(In press).
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Abstract
The biocompatibility, biodegradability, and responsiveness of poly(β‐amino esters) (PBAEs) has led to their widespread use as biomaterials for drug and gene delivery. Nonetheless, the step‐growth polymerization mechanism that yields PBAEs limits the scope for their structural optimization toward specific applications because of limited monomer choice and end‐group modifications. Moreover, to date the post‐synthetic functionalization of PBAEs has relied on grafting‐to approaches, challenged by the need for efficient polymer–polymer coupling and potentially difficult post‐conjugation purification. Here a novel grafting‐from approach to grow reversible addition–fragmentation chain transfer (RAFT) polymers from a PBAE scaffold is described. This is achieved through PBAE conversion into a macromolecular chain transfer agent through a multistep capping procedure, followed by RAFT polymerization with a range of monomers to produce PBAE–RAFT hybrid triblock copolymers. Following successful synthesis, the potential biological applications of these ABA triblock copolymers are illustrated through assembly into polymeric micelles and encapsulation of a model hydrophobic drug, followed by successful nanoparticle (NP) uptake in breast cancer cells. The findings demonstrate this novel synthetic methodology can expand the scope of PBAEs as biomaterials.
| Type: | Article |
|---|---|
| Title: | Hybrid Poly(<i>β</i>‐amino ester) Triblock Copolymers Utilizing a RAFT Polymerization Grafting‐From Methodology |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/macp.202300262 |
| Publisher version: | https://doi.org/10.1002/macp.202300262 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Biomaterials, grafting-from, hydrophobic drug delivery, poly(-amino esters), RAFT, Triblock copolymer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10181021 |
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