McGuire, Katie;
He, Suhang;
Gracie, Jennifer;
Bryson, Charlotte;
Zheng, Dazhong;
Clark, Alasdair W;
Koehnke, Jesko;
... Peveler, William J; + view all
(2023)
Supramolecular Click Chemistry for Surface Modification of Quantum Dots Mediated by Cucurbit[7]uril.
ACS Nano
10.1021/acsnano.3c06601.
(In press).
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Abstract
Cucurbiturils (CBs), barrel-shaped macrocyclic molecules, are capable of self-assembling at the surface of nanomaterials in their native state, via their carbonyl-ringed portals. However, the symmetrical two-portal structure typically leads to aggregated nanomaterials. We demonstrate that fluorescent quantum dot (QD) aggregates linked with CBs can be broken-up, retaining CBs adsorbed at their surface, via inclusion of guests in the CB cavity. Simultaneously, the QD surface is modified by a functional tail on the guest, thus the high affinity host-guest binding (logKa > 9) enables a non-covalent, click-like modification of the nanoparticles in aqueous solution. We achieved excellent modification efficiency in several functional QD conjugates as protein labels. Inclusion of weaker-binding guests (logKa = 4-6) enables subsequent displacement with stronger binders, realising modular switchable surface chemistries. Our general "hook-and-eye" approach to host-guest chemistry at nanomaterial interfaces will lead to divergent routes for nano-architectures with rich functionalities for theranostics and photonics in aqueous systems.
| Type: | Article |
|---|---|
| Title: | Supramolecular Click Chemistry for Surface Modification of Quantum Dots Mediated by Cucurbit[7]uril |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsnano.3c06601 |
| Publisher version: | https://doi.org/10.1021/acsnano.3c06601 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0. |
| Keywords: | click-chemistry, cucurbiturils, host−guest complexes, nanoparticles, quantum dots |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10180872 |
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