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The Effects of Antimicrobial Mouthwashes on Systemic Disease: What Is the Evidence?

Alrashdan, Mohammad S; Leao, Jair Carneiro; Doble, Amazon; McCullough, Michael; Porter, Stephen; (2023) The Effects of Antimicrobial Mouthwashes on Systemic Disease: What Is the Evidence? International Dental Journal 10.1016/j.identj.2023.08.012. (In press). Green open access

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Abstract

The potential association between antimicrobial mouthwash use and systemic health has gained attention in recent years with reports highlighting how some common systemic conditions are influenced by the use of different types of mouthwashes. In this context, links between mouthwash use and cardiovascular disease, diabetes mellitus, oral cancer, Alzheimer's disease, and preeclampsia have been proposed, albeit with limited levels of evidence. Chlorhexidine mouthwash in particular has been the most widely studied agent while available data on other types of over-the-counter mouthwashes are generally scarce. Furthermore, there is currently no evidence-based recommendations on the appropriate use of mouthwashes during pregnancy. This article will present the current evidence on the association between mouthwash use and the aforementioned conditions with emphasis on the mechanisms that may underlie such an association.

Type: Article
Title: The Effects of Antimicrobial Mouthwashes on Systemic Disease: What Is the Evidence?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.identj.2023.08.012
Publisher version: https://doi.org/10.1016/j.identj.2023.08.012
Language: English
Additional information: © 2023 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Keywords: Cardiovascular disease, Chlorhexidine, Mouthwash, Periodontitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10180579
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