Gill, Upkar S;
Peppa, Dimitra;
(2024)
Pegylated interferon-α for chronic hepatitis B…not ready to be shelved yet! new insights on its role using single-cell transcriptomics.
Hepatology
, 79
(1)
pp. 18-20.
10.1097/HEP.0000000000000560.
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Abstract
Pegylated-Interferon alpha (PegIFN-α) is a treatment option for chronic hepatitis B (CHB) but has limited efficacy. It has both immune modulatory and antiviral capacity, however the mechanisms of PegIFN-α in relation to CHB pathogenesis remain understudied. The current editorial reviews a recent study related to the in-vivo use of PegIFN-α using single-cell RNA sequencing (scRNA-seq) technology. PegIFN-α reverts the transcriptome profile of treated samples close to that of the healthy population, diminishing the pro-inflammatory genes and 'inflammatory scores' which will be important for the HBV-cure program.
| Type: | Article |
|---|---|
| Title: | Pegylated interferon-α for chronic hepatitis B…not ready to be shelved yet! new insights on its role using single-cell transcriptomics |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/HEP.0000000000000560 |
| Publisher version: | https://doi.org/10.1097/HEP.0000000000000560 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Hepatitis B, Pegylated-Interferon alpha, single-cell RNA sequencing, monocytes, NK cells, T cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10179337 |
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