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Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia

Stimpson, Madeleine L; Wolf, Julia; Charbit, Bruno; Williams, Emily L; Lait, Philippa JP; Schewitz-Bowers, Lauren P; Lee, Richard WJ; (2023) Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia. British Journal of Haematology 10.1111/bjh.19144. (In press). Green open access

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Abstract

Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid naïve ITP patients enrolled in the multicentre FLIGHT trial and found that the numbers of Bregs in their peripheral blood were similar to healthy controls. In contrast, Breg numbers were significantly reduced in ITP patients treated with systemic immunosuppression (glucocorticoids or mycophenolate mofetil). We also demonstrate that glucocorticoid treatment impairs Breg interleukin-10 production via an indirect T-cell-mediated mechanism.

Type: Article
Title: Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bjh.19144
Publisher version: https://doi.org/10.1111/bjh.19144
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Bregs, ITP, cytokines, glucocorticoids
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10179164
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