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Cancer cell-intrinsic mechanisms driving acquired immune tolerance

Ghorani, Ehsan; Swanton, Charles; Quezada, Sergio A; (2023) Cancer cell-intrinsic mechanisms driving acquired immune tolerance. Immunity , 56 (10) pp. 2270-2295. 10.1016/j.immuni.2023.09.004. Green open access

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Abstract

Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host immune system and evade the cycle of immune recognition and destruction. Here, we review the current understanding of the cancer cell-intrinsic factors driving immune evasion. We focus on T cells as key effectors of anti-cancer immunity and argue that cancer cells evade immune destruction by gaining control over pathways that usually serve to maintain physiological tolerance to self. Using this framework, we place recent mechanistic advances in the understanding of cancer immune evasion into broad categories of control over T cell localization, antigen recognition, and acquisition of optimal effector function. We discuss the redundancy in the pathways involved and identify knowledge gaps that must be overcome to better target immune evasion, including the need for better, routinely available tools that incorporate the growing understanding of evasion mechanisms to stratify patients for therapy and trials.

Type: Article
Title: Cancer cell-intrinsic mechanisms driving acquired immune tolerance
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.immuni.2023.09.004
Publisher version: https://doi.org/10.1016/j.immuni.2023.09.004
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Cancer immune evasion; acquired tolerance; cancer immunotherapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10179098
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