Saraf, Udit;
Batla, Amit;
Sakakibara, Ryuji;
Panicker, Jalesh N;
(2023)
The Impact of Polypharmacy on Management of Lower Urinary Tract Symptoms in Parkinson's Disease.
Drugs Aging
, 40
(10)
pp. 909-917.
10.1007/s40266-023-01060-2.
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Abstract
Lower urinary tract (LUT) symptoms are a common presentation of autonomic dysfunction in Parkinson's disease (PD). Symptoms significantly impact quality of life and are associated with worsening of motor symptoms and increased risk for falls. Different medical co-morbidities can often contribute to LUT symptoms, and a thorough evaluation therefore becomes essential. The effects of medications used for Parkinson's disease and other co-existing medical co-morbidities on LUT symptoms is often underestimated. Treatment options include behavioural therapy, oral agents such as antimuscarinic and beta-3 receptor agonist agents, botulinum toxin and neuromodulation. The first-line oral agents cause adverse effects that may exacerbate pre-existing Parkinson's disease-related symptoms. Furthermore, these oral agents can interact with other medications used in Parkinson's disease, and the challenges posed by interactions on pharmacological effects and metabolism are discussed. Knowledge about drug interactions can help in effective management of such patients and mitigate the risks for developing adverse effects.
| Type: | Article |
|---|---|
| Title: | The Impact of Polypharmacy on Management of Lower Urinary Tract Symptoms in Parkinson's Disease |
| Location: | New Zealand |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s40266-023-01060-2 |
| Publisher version: | https://doi.org/10.1007/s40266-023-01060-2 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Pharmacology & Pharmacy, OVERACTIVE BLADDER QUESTIONNAIRE, TIBIAL NERVE-STIMULATION, BOTULINUM-TOXIN-A, QUALITY-OF-LIFE, ANTIMUSCARINIC DRUGS, VOIDING DYSFUNCTION, COGNITIVE FUNCTION, NONMOTOR SYMPTOMS, LEWY BODIES, OLDER |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10179047 |
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