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In Vivo Detection of Retinal Ganglion Cell Stress in Rodents with DARC

Hill, Daniel; Choi, Soyoung; Cordeiro, Maria Francesca; (2023) In Vivo Detection of Retinal Ganglion Cell Stress in Rodents with DARC. Methods in Molecular Biology , 2708 pp. 123-129. 10.1007/978-1-0716-3409-7_13.

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Abstract

DARC (detection of apoptosing retinal cells) uses fluorescently tagged Annexin A5 to identify retinal apoptosis non-invasively in vivo using a confocal laser scanning ophthalmoscope (cSLO). This can provide insights into the presence and progression of disease pathology and the efficacy of neuroprotective intervention. The methods of administration, imaging, and quantification of DARC, including the operation of the cSLO, are described here.

Type: Article
Title: In Vivo Detection of Retinal Ganglion Cell Stress in Rodents with DARC
Location: United States
DOI: 10.1007/978-1-0716-3409-7_13
Publisher version: https://doi.org/10.1007/978-1-0716-3409-7_13
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Annexin, Annexin A5, Apoptosis, cSLO, DARC, Neurodegeneration, Retina
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10178899
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